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A molecule that can target cancer-enabling RNA directly is a fascinating step. Curious how selective it is and whether similar RNA targets could be approached this way in future studies.
Interesting paper. G4 motifs are really common and important and interacting with them is nothing new. The addition of a TAC is the only novel thing I see here. I’d be surprised if this approach was specific enough to confer therapeutic benefit without causing problems, especially since the ISCH scaffold was originally used as a general G4 probe rather than a ligand for this specific RNA. To my knowledge, no other G4 ligands have been approved for therapeutic use (though there are some promising options in trials)
Our world is a loud and complex one. The idea of something which quietly, simply does its job without fifty crippling side-effects and caveats and externalities is a relief.
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User: u/sus1227
Permalink: https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202512715
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A molecule that can target cancer-enabling RNA directly is a fascinating step. Curious how selective it is and whether similar RNA targets could be approached this way in future studies.
In mice?
What else does it erase?
I heard cancer-enabling RNA stole its car and killed its dog
Is dog-killing a benefit for mice?
Interesting paper. G4 motifs are really common and important and interacting with them is nothing new. The addition of a TAC is the only novel thing I see here. I’d be surprised if this approach was specific enough to confer therapeutic benefit without causing problems, especially since the ISCH scaffold was originally used as a general G4 probe rather than a ligand for this specific RNA. To my knowledge, no other G4 ligands have been approved for therapeutic use (though there are some promising options in trials)
r/unnecessarilyquiet - people weren't kidding about so many headlines including "quietly" for no reason these days
Our world is a loud and complex one. The idea of something which quietly, simply does its job without fifty crippling side-effects and caveats and externalities is a relief.
If it's half as good as the title is cool, it will be tremendous. I hope we find a lot of cures for cancer in the upcoming years. It's long due.