I’ve been on a GLP-1 for almost a year, and so the massive nausea has greatly subsided. HOWEVER! For the second time I had to bolt to the WC after Tuesday’s tread block (first time was after CMIYC). I felt great, and got over 3.3 miles, the moment I hit the WR my Alani Nu and water started creeping up. I had to bolt to the loo and puke once. Then felt fine!
I’m so scared to go too hard/fast now in fear of that happening again! Anyone else have this happen? So embarrassing 🤦🏼♀️
I had to stop the tread many times on ozempic because I’d want to puke when my HR got elevated enough. It significantly impacted my work out.
Woot woottttttt
If you’re interested I can give you the whole physiological breakdown of why this happens. If not, just know you’re not broken or crazy. God after the dri tri and the 250 rowing BM I barely made it to the bathroom. The issue is your heart rate spike and the signal completely bypassing the nausea center and straight to the vomit NOW part of your brain. The secret to avoiding it is, unfortunately, avoiding the sharp and fast heart rate spikes. Ramp up slower and decrease intensity a bit.
Science nerd here so def interested! Yesterday I couldn’t go as fast as I wanted as I felt that pressure in the back of my throat at every WR.🤦🏼♀️
A lot of people on Zepbound or tirzepatide end up vomiting during exercise, and it’s actually a known physiologic response, not typical nausea. It has to do with how GLP1 meds change autonomic nervous system responses when you shift into exertion.
These meds slow gastric emptying and increase vagal tone, so your body sits more in a rest and digest state at baseline. When you start exercising and especially when you go into a hard pus or AO, your system has to flip fast into sympathetic drive. Heart rate jumps, blood flow shifts to skeletal muscle, breathing increases, and that rapid switch sends a big signal through the vagus nerve.
That autonomic surge can directly activate the vomiting reflex through the nucleus tractus solitarius in the brainstem, which coordinates inputs from the vagus nerve, baroreceptors, and the gut. This pathway can bypass the area postrema, which is the part of the brain involved in chemical nausea. That’s why a lot of people say they didn’t feel nauseated first, they just abruptly threw up.
GLP1 meds also make the gut-brain signaling more sensitive, so the threshold for triggering that reflex is lower than usual. Add in things like stomach distention, CO2 and lactate buildup, dehydration, or overheating, and it becomes even easier to trip that brainstem reflex.
It’s basically a reflex shutdown response, similar to the kind of sudden vomiting you can see with extreme pain, heat stress, or rapid drops in blood pressure.
To reduce the risk, it helps to warm up slowly so your heart rate doesn’t spike, avoid exercising right after eating, stay hydrated and use electrolytes, be cautious with very high intensity workouts when you’ve just increased your dose, and back off if you start overheating.
It’s common on these meds and annoying as hell, but for most people it improves once the dose stabilizes and the autonomic system adapts.
This is so interesting! I started low dose (.25) Ozempic 6 weeks ago for binge eating and notice I sweat way more working out on day 2 post injection. I was wondering if the meds were impacting how my body responds to work outs so it's very interesting to read this! Thank you!
I am a retired RN, data nerd, and research enthusiast with a raging case of ADHD that showcases itself as hyperfocusing. I quit taking my Vyvanse when I started zepbound because it was nearly impossible to eat and I’m retired so who cares if my adhd symptoms are around.
Anyway, when the sudden projectile vomiting started happening, I was determined to find out physiologically why. I mean I had been in the army, through basic training, and combat, pushing my body to extreme limits and never once vomited from exertion. Sure I was younger then but it still seemed odd that I was now vomiting after an AO 250 meter row that wasn’t even a TRUE AO. So I did what I do and researched the hell out of it for days on end.
If you’d also like to learn about neurogenic itch injection site reactions, how to find a properly fitting bra, discuss ER reruns in excrutiating detail, and/or learn about worms, I’m your woman.
Can we be friends😂🧡
You wanna go do karate in the garage?
Has it helped? I’m on wegovy for the same thing for 4 months and it hasn’t helped
Which is exactly why after one dose I’m stopping tirzepatide. The side effects are not worth it.
I have had very little side effects and have lost 87lbs in 8 months, 93% of which, according to Dexa scans, was fat. So ya know YMMV
Ok I’m such a super nerd this is awesome! Thank you! The two times it has happened to me actually was at the end of a LONG block. Not an AO per se. Tuesday was that damn 18 min pyramid and the 430 build at the end. And CMIYC I held the same speed the whole time, BUT! You’re so right in that the nausea isn’t there. In fact any time I’ve ever been physically sick on sema there was no nausea. Outside of these two times, the only other times I’ve been sick were when I woke up feeling hungry. If I have no food in my stomach, that triggers my gag reflexes the most which is odd!
Does this go away after stopping them?
Yes it will eventually, although it’s not GLP1 specific, GLP1s just lower the threshold. Anyone can trigger this response.
That’s good to know and seems to align with when I’m throwing up!
Great info and would you agree this not related to GLP1 use?
No, it’s completely related to GLP1 use, but can happen to anyone if they push past the breaking point. I just made a really long post explaining all of it and the pathways and what’s overridden in the brain to cause this. GLP1 use just lessens the threshold.
I've been on Terzepitide and have never experienced any problems. I'm sorry you've had to deal with that. It sounds miserable.
This
I was on it last year and had general nausea but it never materialized or was worse during workouts, I mainly felt it around eating
Same
not GLP user but i’ve done this! tried to push through an extra hard all out only to cut it short to vom.
i came back and started running again and the coach asked if i was okay. i said “yeah just threw up” and kept running. they looked horrified lol
😂
I remember doing this in college track 😩Coach was not horrified though, just was like welcome to the team 😬
😲
I experience this as well, mostly during AO to WR. I noticed I wasn’t getting as nauseous once I tried the following: -ate the tiniest snack before my class (I go to the 615 so eating that early is a challenge), something like an applesauce pouch, half of a yogurt or like 3 bites of a protein bar. -switched to starting on the floor/rower to allow my body to warm up -took SIPS of water with an electrolyte packet; I have thrown up an entire 32 ounce owala in the parking lot 😂 -allowed myself 45 minutes to an hour to get up and ready for my workout to like alert my body that it’s not just rolling out of bed for work
It was a lot of trial/error and I still get nauseous the morning after injection day but those modifications have helped a ton. Hope this helps!!!
Funnily enough I did IF/ADF for a few years so I always workout out fasted. I now have to have a protein bar or I’m gagging.
I’m not on a GLP-1, but I regularly feel the need to puke if I spend longer than a minute in the red zone.
I just started GLP so definitely see how they could contribute to nausea, but I also used to puke on really hard workouts regardless.
I've been on Zepbound for 18 months, and I've had cases of runner's trots after some particularly challenging tread blocks, but I don't think it's the medication, heh.
I am on Zepbound also and have not had any nausea at all.
Same here.
What are runners trots?😂
Diarrhea
Only issue I ever had on it was constipation but that was me getting my diet adjusted to the medication.
Only after DriTri
OMG I definitely would after or during DriTri. Nope!😂
I’ve been on Tirzepatide for 10 months now and have nausea a lot of the time, not necessarily specific to exertion. I always have zofran on me wherever I go because I hate puking. I’ve vomited 3 times in these 10 months, never at OrangeTheory. The timing of my vomiting seems really random and not at any particular timeframe after injection or doing any particular activity.
Yeah I've noticed after intense workouts I feel like puking and once a little started to come up lol. I usually just need a moment to chill though and the feeling subsides. It's not so bad that it keeps me from going hard.
The intentional breathing I was doing ….LAWWWWWD🤭
Girllll, I’ve learned it’s better just to get it out. I projectile vomit hard and feel like shit for a good minute or so but afterwards I’m right as rain and able to continue my workout… just more carefully.
😆
I'm on tirz and have luckily not had much nausea. I know my HR goes a bit higher on it than it did before the GLP1. - My hubby DID have nausea on sema though. - Hope you feel better!
My HR is higher too - finally getting splats again!🤣
I've been on wegovy since Nov 2024. I have only felt like vomiting once and I think it was dri tri. The first six months or so I definitely was hyper aware of my HR spiking.
Same!!!! I haven’t ever thrown up on this drug EXCEPT when I run. It sucks! I think I’ve thrown up 4 times at OT now and - embarrassingly - once outside after a run. I did a Tread50 today and managed not to hurl and it felt so good to actually get a decent run in, but I’m actually scared of the treadmills now and they’ve always been my favorite.
Yes! I’ve never ever thrown up working out ever and I literally work in fitness so this was erm…….a new experience. The fact that it catches you by surprise it what’s scary☠️😂
Omg I had to switch from jogging to power walking because ozempic has me so nauseous all the time anymore.
It will get better I promise. These were just two REALLY intense tread days.
I’m not on a GLP-1 but I have exercise induced nausea that gets worse when I get overheated. I’ve had it checked out and ran tests and several docs have all said some people just have that and have to power through it.
But I have found a trick - I buy boxes of the little alcohol wipes like nurses use before they give you a shot. I bring 1-2 packets in with me, tear off one side, and breathe in the alcohol smell when I start to get queasy. It usually at least takes the edge off enough to keep going. My coaches are all used to seeing the weird lady snorting her alcohol wipes in class now 😆😆😆.
I’ve been on Mounjaro for almost 3 years and haven’t experienced this.
Yes - I now do my injections Wednesday night so it is settled for my Sunday and Wednesday classes.
Im on Wegovy (almost a year) and while I haven’t yakked yet, I’ve been pretty damn close.
OMG glad it isn't just me. I've never actually thrown up but I was damn near close. I've even had to leave early because I couldn't bear it anymore
Oh man I lost it once when I was taking the shots and threw up on the mirror behind the treads. It was horrible. I never could get past that. God speed to all of you still in it. 🙏💪
Maybe it’s the garbage in the Alani Nu and drinking that while working out 🤷🏻♀️
I had been up since 4am for work and have one daily before I workout. This has happened twice in a year. Probably running 6.5 miles an hour at a 9% incline and adding speed from there. But ok. 🙄
I puke after hard tread blocks even before GLP's.
Not on GLP-1s, but that Tuesday tread block almost made me puke too!
OTF chose violence that day😂😂😂 I taught it 4 times and then had to take it. I was afraid and rightly so.😂
Tuesday’s tread block was diabolical. I hope you get to feeling better soon!
Ugh, that first 6 months on mounjaro made OTF so difficult. I've been taking it for almost 2 years now and I still refuse to work out the day after my shot due to the nausea and possibility of vomiting.
Is mounjaro the generic version zepbound ?
I throw up nearly every class or before. 🥲 I carry a bag in my leggings just in case. It’s so frustrating.
Wow had no idea of these side effects. Yikes!
Happened to me on the rower at the end of a 3G
I’ve been micro dosing for 10 months on Tirz. I’ve never had an issue. On Reta I would get super dizzy and light headed because my sugar would drop so fast
I’ve been on tirzepatide for about three months. Haven’t experienced this at all, but I also know I felt that way on CMIYC and Capture the Flag anyway! Sorry it happened a second time for you!
My side effect I’ve noticed is less energy in general and some lightheadedness with the explosive movements. I’m still getting around 2000 cals a day, so it might be the blood sugar lowering for me.
How do you pay for it
What's a WC