Honestly not inaccurate with what the immune system does a lot of the time. The reason cancers so bad is cause it normally is a mutation that causes the cell to ignore apoptosis (aka, killing itself cause it was told to) and instead just continues growing
There are lots of other uses too from pruning useless neurons, removing the webbing between your fingers and toes, and killing immune cells that target your own body.
Yep. If the cell detects that something with its processes is going wrong, it's supposed to destroy itself to prevent further harm to the body. Cancer cells skip this check, so they never end up destroying themselves naturally. That's where Killer T cells come in. They detect that a cell is malfunctioning and not self-destructing, so to prevent things from getting out of hand, they forcibly activate the self-destruction response in the rogue cell.
Well killer T cells have multiple ways or dealing with these, easiest is it simply it orders it to commit die, or it has several biological weapons to kills it itself
Yeah, well, pretty accurate, cuz it can't suicide, that would need it to influence it's surroundings to kills it, but no, it just ends it's internal processes, nothing more, so they goofy term isn't that inaccurate
That's correct, it can do this in a number of ways, this cell underwent apoptosis which is controlled cell death, but they can also initiate uncontrolled death, necrosis, which can be both good and bad depending on the situation. Our cells have incredibly complex machinery solely devoted to killing themselves. Even a signal they put out that is often called the "eat me" signal, telling immune cells around them to initiate cell death when the cell is under stress.
It's more like a little guy that goes around with a set of special keys, which he uses to unlock a little door which hides the self destruct button, which he also presses.
Bio-Chemical Environmental engineer here. Contact Mike Sheikh with Bioxytran. They have something that can take care of Glioblastoma. Tell him I sent you. He knows who I am. PM me if you need to
"Although the video compresses about 75 minutes of activity, it’s important to note that it takes the T cell only 10 minutes to kill the cancer cell after recognizing it."
From what i know Every cell is required to kill themselves after a certain point so they don't grow too much. But some cells ignore that and keep growing which is what causes cancer.
No but u can train peoples own T cells to kill their own tumors and then inject them again in the patient, and that is a heavy topic off investigation (car-t).
My father was a recipient of this CAR-T cell treatment and has now been cancer free for 3 years. I am forever grateful to all those scientists and Dr’s working hard to develop and refine this treatment.
Woah that’s about as bad as it gets, and must have been scary to go through. I’m so sorry 😢 But it’s absolutely awesome that your dad is healthy and cancer free now! We need more happy success stories like this in life
It’s a little more complicated than simply “harvesting” them. Current cancer drugs such as chemotherapy initially eradicates T cell count basically, but also aggressively attacks the cancer cells which in turn activates the surviving T cells and stimulates production of new ones. Kind of a double edged sword because it increases ur risk to infection before activating a fresh set of T cells to fight
Other immunotherapy treatments increase and enhance the T cell performance.
The toxins would kill all cells, not just cancer cells, the reason it works with the t cells is because they directly target the cancer cell, also I don't know if it would be able to diffuse into cells from the outside without being injected by the t cell.
The toxins contain molecules that punch holes in the cell membrane which then allows a second part of the toxin, an enzyme that destroy proteins, to enter the cell. When T cells do it, it's targeted at specific cells they latch onto. If you just pump those chemicals into your body...you're going to have a bad time. Functional cell membranes and functional proteins are essential for staying alive.
The toxin doesn’t care what cell it’s in, it will destroy it. An injection wouldn’t be safe because it can kill regular body cells as well. Simply put The T Cell recognizes the cell as a foreign body by structures on the surface of the cell it’s been trained to “remember”- you’ll notice the T cell is attached to the cancerous cell when this happens
We harvest the T cells train them to recognize a certain antigen on the cancer cells. Then we inject the T cells back into the patent. The T cells then kill off the targeted cell type.
Yes, there are both existing FDA approved CAR-T treatments and new ones in clinical trials. It involves collecting the patients’ cells, engineering, multiplying, and then reinfusing their T-cells. The engineering part is complex, as is finding effective surface cell receptors that work for each cancer / tumor type. This is a big part of why it isn’t universal for all cancer types - they still are researching what is effective.
I wish I could have shown this to my mum when she got diagnosed with breast cancer. Would have helped her realize it’s not just her mind fighting on its own, her body is fighting for her life right alongside her and she didn’t even know.
What am I looking at? Is the T-cell the long tube-like thing coming from the top of the screen? Does it pop the cancer cell or suck it up like a piece of spaghetti? I’m sure it took a lot of effort to capture this shot, but it’s not very clear to a layman.
When someone gets cancer, is it then because there are too many cancer cells for these T-cells to kill? Or are these like special T-cells that can target cancer cells?
Your body is constantly inadvertently creating cancer cells. T cells do their business and you never know about it. Some cancer cells mutate in a way where T cells won't recognise as something they should be handling or stops the mechanism they use to kill them from working.That's when there is a bit of a problem.
Cancer cells propagate when they're able to successfully hide the fact that they're cancer cells. They crop up constantly and they're usually easy for your immune system to detect and kill, but once in a while one will slip under the radar and you have a problem.
So basically there’s essentially code written into the cell to.. die Edit: “alright, my work here is done. Now where did I put the instruction to kill myself?”
T cell rolls along the surface of the cancer cell. Tons of shit is happening, but it all culminates in the T cell recognizing hte cancer cell as a baddy.
T cell then gives it a kiss of death. It literally forms a synapse (very similar to a neuron). Two cell membranes essentially kissing.
Then the T cell kisses the cancer cell so hard, that it releases a bunch of extremely toxic molecules. One really special one is called GRANZYME. These are enzymes force the cancer to kill itself through a process called apoptosis which caused the membrane to invert and shrivel up on itself.
So T cell synapse-> granzyme release -> cancer apoptosis -> rapid membrane inversion -> cancer death.
This is all done in a dish, but generally happens in us all the time vs virus-infected cells and cancer!
This is cool as fuck
what a fucking homie
https://preview.redd.it/68fs2b5b8m6g1.jpeg?width=3288&format=pjpg&auto=webp&s=40c1b8e45d40a6a4516c6688f1807396a51fe75e
Which eps is this?
Anatomy park in i think season 1.
If the mechanism is the same with B-Cell lymphoma, I can attest this process is achingly painful.
Diffused large B Cell here. 2 years of hell and seven years post transplant.
https://preview.redd.it/sxxqgg4kig6g1.jpeg?width=320&format=pjpg&auto=webp&s=681862252e00ff6f85e59ef14669747685654515
I’m crying, added to the collection.
https://preview.redd.it/djd5x7teui6g1.jpeg?width=828&format=pjpg&auto=webp&s=1c1f596499ca8dca66307712055f04eb416d7908
Dude used a railgun or what
"The T cell secretes toxins (red waves), which trigger the cell death response in the cancer cell, causing it to shrivel up and die."
Apparently
Told it to go kill itself.
Murder yo self fool
My first award! Thank you kind stranger.
And thanks for my second award!
How come I can't see any? Looks like you're just talking to yourself
I see them but he's still talking to himself lol
Sure, when he talks to himself, he gets awards, but when I do it, it's weird.
https://preview.redd.it/lz4eoq38kg6g1.jpeg?width=2360&format=pjpg&auto=webp&s=e4f86b9f2ac18924a86d95337cb8a0f886431f75
https://preview.redd.it/dpf91rh9li6g1.jpeg?width=739&format=pjpg&auto=webp&s=9607f000ffe80e55e9169c23d8cf116871b9a846
Trash talk it to death
Literally.
Low T(ier) Cell
Part of what makes cancer cancer is the cells not undergoing apoptosis, or programmed cell death, so your description is accurate.
Honestly not inaccurate with what the immune system does a lot of the time. The reason cancers so bad is cause it normally is a mutation that causes the cell to ignore apoptosis (aka, killing itself cause it was told to) and instead just continues growing
Frieren moment
Power Word: Kill
So basically there’s essentially code written into the cell to.. die
Programmed cell death! Apoptosis. I think the mitochondria are involved and suck in all the scaffolding/microtubules all at once causing a collapse.
Mitochondria is the powerhouse of the cell, after all.
Mitochondria: both the giver and the taker of [cell] life.
Blessed be the Mitochondria!
(... sorry. Just sounded like a liturgy.)
There is a whole process called apoptosis. It's really cool and used to kill cells that might have a mutation or does have a cancerous mutation.
IMHO apoptosis is one of the coolest and best examples of an organism as a whole being more important than the individual cell.
There are lots of other uses too from pruning useless neurons, removing the webbing between your fingers and toes, and killing immune cells that target your own body.
Yep. If the cell detects that something with its processes is going wrong, it's supposed to destroy itself to prevent further harm to the body. Cancer cells skip this check, so they never end up destroying themselves naturally. That's where Killer T cells come in. They detect that a cell is malfunctioning and not self-destructing, so to prevent things from getting out of hand, they forcibly activate the self-destruction response in the rogue cell.
Your cells not self-destructing when they're supposed to is how cancer works actually.
Red Waves of Death is my new band
Well killer T cells have multiple ways or dealing with these, easiest is it simply it orders it to commit die, or it has several biological weapons to kills it itself
"Commit die" is just ,👌
Yeah, well, pretty accurate, cuz it can't suicide, that would need it to influence it's surroundings to kills it, but no, it just ends it's internal processes, nothing more, so they goofy term isn't that inaccurate
i read that as a git command. git commit die. git push pop!
Sudo commit die
sudo rm -rf / --no-preserve-root
“Commit die now “ !
Sounds like the most badass Pokemon attack.
The process is called T cell mediated apoptosis if you’d like to look it up
It looked like it activated a kill switch. It basically told the cancer cell to kill itself.
That's correct, it can do this in a number of ways, this cell underwent apoptosis which is controlled cell death, but they can also initiate uncontrolled death, necrosis, which can be both good and bad depending on the situation. Our cells have incredibly complex machinery solely devoted to killing themselves. Even a signal they put out that is often called the "eat me" signal, telling immune cells around them to initiate cell death when the cell is under stress.
It's more like a little guy that goes around with a set of special keys, which he uses to unlock a little door which hides the self destruct button, which he also presses.
the cancer cell really said
Who modelled this... and why?
It's by Oliver Latta AKA Extraweg. Fun fact... he did the Severance intro titles. https://www.youtube.com/@extraweg
I think it's a depiction of "cringe" but in a way that humans can't do.
As to who? No idea
Me when I touch the food bits in the plughole after washing up
T cell just stood there like,
Edit:OMG my first reward! Thank you!
He hit an emote after a kill
T bagged it
T cell aint about that B shit
called the homies to watch and everything
Gettin jiggy wit it
Fuck Cancer!
100% agree. I hope my t-cells saw this and went after my glioblastoma.
For what it's worth, I too hope your TCells see this and go full super Saiyan lvl 2 and fuck that cancer up all kinds of ways from Sunday
Thank you! While you’re at it…uhh…can you use your semi-divinity to advocate to the cosmos on my behalf?
YO COSMOS! MY GUY NEEDS SOME CANCER GONE! THINK YOU COULD DO THAT FOR ME?!
Thank you!
Bet your ass I will. Just a little secret though, you too are semi divine:)
yo COSMOS, this guy got some CANCER, cut that shit out!
You have my feels, and wishes.
……. I need to run a dragon ball joke by someone now. Thank you 😂.
Also yes, fuck cancer
Godspeed buddy
Fuck glioblastoma especially. Go T cells!
Absolutely agree on this one! And thank you!!
Bio-Chemical Environmental engineer here. Contact Mike Sheikh with Bioxytran. They have something that can take care of Glioblastoma. Tell him I sent you. He knows who I am. PM me if you need to
Ok. I will PM you later. Thank you
I had to put down a soul mate of a cat a few months ago. Seriously fuck cancer
I feel you. I hope you are doing ok x
FUCK CANCER
What
.___.
Hell ya, he did it!
https://preview.redd.it/k25hdkbdcg6g1.jpeg?width=290&format=pjpg&auto=webp&s=7b3fcd426842bb5ca2cb3f31876ca8ed50523d41
Source: Cells at Work
Perforin Canon Punch!
elite ball knowledge
Thank you for your hard work!
I loved that show
I was specifically looking for this reference in here.
Yep I was looking for this
Way to go T cell. Fuck cancer
https://preview.redd.it/0749ppnxvg6g1.jpeg?width=1280&format=pjpg&auto=webp&s=267fd0796460463652b7b1574f3eae8971b59689
I like that his homies came to see the show
Over how much time is this?
"Although the video compresses about 75 minutes of activity, it’s important to note that it takes the T cell only 10 minutes to kill the cancer cell after recognizing it."
Very cool
How does it recognise cancer?
From what i know Every cell is required to kill themselves after a certain point so they don't grow too much. But some cells ignore that and keep growing which is what causes cancer.
So how does that logic jive with the whole ten day water only fasting that supposedly kills off 90% of cancer cells?
I've never heard something like that, it's probably misinformation.
Honest question. Can we harvest those T cells and get their toxins so we can create an injection to fight off cancer cells.
Unless it's already being done.
No but u can train peoples own T cells to kill their own tumors and then inject them again in the patient, and that is a heavy topic off investigation (car-t).
Fuck yeah, put my cells through college
More like boot camp.
T- cell boots just being boots
West Point. You get two in one.
The CAR-T are not trained in the sense of like a vaccine (that's also being generated for cancers).
CAR-T literally are retrofitted with a blastercannon that has lock-on technology. They effectively headshot the tumor.
That said, the technology is still in its infancy, and we're discovering ways to make them 10x more effective.
My father was a recipient of this CAR-T cell treatment and has now been cancer free for 3 years. I am forever grateful to all those scientists and Dr’s working hard to develop and refine this treatment.
If we all manage to vote correctly, we might have some of this wonderful technology in the future!
That is so cool! Which cancer did he have?
He had stage 4 Lymphoma
Woah that’s about as bad as it gets, and must have been scary to go through. I’m so sorry 😢 But it’s absolutely awesome that your dad is healthy and cancer free now! We need more happy success stories like this in life
Or T cell Engagers which basically lasso the already existing T cells and kiss-kiss smash them together with the cancer cells.
I had this treatment done and I'm 4 years cancer free. Not saying this is exactly what "cured" it for me, but I wouldn't doubt that it helped.
It’s a little more complicated than simply “harvesting” them. Current cancer drugs such as chemotherapy initially eradicates T cell count basically, but also aggressively attacks the cancer cells which in turn activates the surviving T cells and stimulates production of new ones. Kind of a double edged sword because it increases ur risk to infection before activating a fresh set of T cells to fight
Other immunotherapy treatments increase and enhance the T cell performance.
The toxins would kill all cells, not just cancer cells, the reason it works with the t cells is because they directly target the cancer cell, also I don't know if it would be able to diffuse into cells from the outside without being injected by the t cell.
The toxins contain molecules that punch holes in the cell membrane which then allows a second part of the toxin, an enzyme that destroy proteins, to enter the cell. When T cells do it, it's targeted at specific cells they latch onto. If you just pump those chemicals into your body...you're going to have a bad time. Functional cell membranes and functional proteins are essential for staying alive.
Doesn't work on cells which mutated to ignore the toxins. Those are the cancerous cells that become malignant tumors.
Yeah but then you loose the sensitivity to inject it directly in only the right cells so only the cancer cells die and not all the healthy ones too.
The toxin doesn’t care what cell it’s in, it will destroy it. An injection wouldn’t be safe because it can kill regular body cells as well. Simply put The T Cell recognizes the cell as a foreign body by structures on the surface of the cell it’s been trained to “remember”- you’ll notice the T cell is attached to the cancerous cell when this happens
https://en.wikipedia.org/wiki/CAR_T_cell
Kind of. Its called CAR T cell therapy.
We harvest the T cells train them to recognize a certain antigen on the cancer cells. Then we inject the T cells back into the patent. The T cells then kill off the targeted cell type.
Thats like taking a shotgun to shoot precision targets
The first part, yes, it's more or less immunotherapy. Regarding the toxin injections, the tricky part is targeting only the cancer cells.
No. But you can modulate t cells to be more aggressive towards cancer cells, increase their proliferation or reduce exhaustion.
T cells are like smart bombs for the immune system: you don't want those toxins getting into the wrong places.
Yes, there are both existing FDA approved CAR-T treatments and new ones in clinical trials. It involves collecting the patients’ cells, engineering, multiplying, and then reinfusing their T-cells. The engineering part is complex, as is finding effective surface cell receptors that work for each cancer / tumor type. This is a big part of why it isn’t universal for all cancer types - they still are researching what is effective.
T-cell just went:
Git rekt
T Cell casts Power Word - KILL
If they can kill cancer that's incredible. But why a name that reminds me of resident evil.
The T virus
Flawless victory
Is right! F cancer
Funny, my cancer was my white blood cells killing my red blood cells(ALL.)
https://i.redd.it/h5i437560i6g1.gif
It's so sad Steve Jobs died of ligma
Who the hell is Steve Jobs?
Ligma balls
Omae wa mou shindeiru!
https://preview.redd.it/e1h3idt16h6g1.jpeg?width=720&format=pjpg&auto=webp&s=8038de675d82ece90acbe051f0cc112d164f63bc
That t-cell to the cancer cell
I wish I could have shown this to my mum when she got diagnosed with breast cancer. Would have helped her realize it’s not just her mind fighting on its own, her body is fighting for her life right alongside her and she didn’t even know.
What am I looking at? Is the T-cell the long tube-like thing coming from the top of the screen? Does it pop the cancer cell or suck it up like a piece of spaghetti? I’m sure it took a lot of effort to capture this shot, but it’s not very clear to a layman.
As you can see on the bottom left, the t-cell is the pink thing
Doing some extra googling:
"The T cell secretes toxins (red waves), which trigger the cell death response in the cancer cell, causing it to shrivel up and die."
T cell used avada kedavra!
-It's super effective!-
Thanks.
PSA to watch Cells at Work. It's an anime about the human body and is pretty fun and educational, even if you're not a big anime fan.
https://preview.redd.it/3aq2oyjfuh6g1.jpeg?width=958&format=pjpg&auto=webp&s=b7ef60bf4f0b04fb144c9a5d04fb684b2a77c5d4
She's just doing her job
https://preview.redd.it/u0xhrs3sfk6g1.jpeg?width=480&format=pjpg&auto=webp&s=c62f069d5d7808db161415638f014271b654ab02
We had know her in her first version too!
When someone gets cancer, is it then because there are too many cancer cells for these T-cells to kill? Or are these like special T-cells that can target cancer cells?
Your body is constantly inadvertently creating cancer cells. T cells do their business and you never know about it. Some cancer cells mutate in a way where T cells won't recognise as something they should be handling or stops the mechanism they use to kill them from working.That's when there is a bit of a problem.
Cancer cells propagate when they're able to successfully hide the fact that they're cancer cells. They crop up constantly and they're usually easy for your immune system to detect and kill, but once in a while one will slip under the radar and you have a problem.
Yo! T Cell cool af!!
Get wrecked!
Obligatory fuck cancer
The fact we can see this in action is incredible
Fucking A T cell cleaned that cancer cunt's clock!
KAME-HAME-HA!
Yesss!
This would be great with gen 1 Pokémon battle music playing, and the super effective sound effect when the cancer cell shrivels
So basically there’s essentially code written into the cell to.. die Edit: “alright, my work here is done. Now where did I put the instruction to kill myself?”
Fuck that shit up, T!
That little T cell in the top oozing in like “what did I miss?”
Apoptosis bitch
THATS WHAT I LOVE TO SEE!!! GET HIS ASS!!🗣️🗣️
https://i.redd.it/p9e3zl0mpl6g1.gif
Hell yeah fuck that cancer up!
T-Cell uses toxic spit! It's very effective.
It's very cool that we've come so far.
I think I played too many videogames... When I read T-cell I thought of Resident Evil...
Does the T stand for terminator? Because it absolutely demolished that cancer. Good riddance.
So, what exactly am I looking at? Like, how does a cell like that just instantly shrivel up and die?
So T cell is in pink, cancer cell in cyan.
T cell rolls along the surface of the cancer cell. Tons of shit is happening, but it all culminates in the T cell recognizing hte cancer cell as a baddy.
T cell then gives it a kiss of death. It literally forms a synapse (very similar to a neuron). Two cell membranes essentially kissing.
Then the T cell kisses the cancer cell so hard, that it releases a bunch of extremely toxic molecules. One really special one is called GRANZYME. These are enzymes force the cancer to kill itself through a process called apoptosis which caused the membrane to invert and shrivel up on itself.
So T cell synapse-> granzyme release -> cancer apoptosis -> rapid membrane inversion -> cancer death.
This is all done in a dish, but generally happens in us all the time vs virus-infected cells and cancer!
I wanted to see this answered too. Are those purple cells the T-cells? I have no idea what I’m looking at
That's MR T cell to you. Pity the fool cancer cell who gets in that ring.
Go, little T-cell! You can do it!
Watching the cancer cell literally impload is a thing of beauty
I need the anime version of this. Like in Bloodcells at Work
Orcas of the blood.
https://preview.redd.it/tbe3ki9kqg6g1.jpeg?width=1776&format=pjpg&auto=webp&s=bc033e32333e377f548cc03b63de1354e51202c2
T cell just discombobulated that cancer cell
Hell yeah
why does everyone have an award 😭
The other two T Cells come right over saying "you good? You good?"
I pity the fool!
SLAY THAT MASSIVE FUCKER. LET HIM KNOW THAT BODY BELONGS TO YOU, NOT HIM
https://preview.redd.it/sruh688u8l6g1.jpeg?width=527&format=pjpg&auto=webp&s=2e12d1a638bf444afb26771e62e2640cd15d7820
They're hard at work
Hell yeah! Fuck cancer.
The killer T cell: