What if someone was originally diagnosed Schizoaffective. They had a change in providers and years gap between care. They then get diagnosed Major Depressive Disorder with a psychotic break not likely to reoccur?
This all based on their self-disclosure and hiding symptoms/issues.
I’d say it’s possible. It’s a spectrum and clinically about 10% of people have psychosis at some point in their lives but only about 1.5% qualify for a schizo- diagnosis. I’m NAD so it’s a difficult concept for me.
I can’t say if that’s appropriate in that individual.
The more I have looked, the more it seems like there is a lot of subjectivity and overlap in diagnoses. I came across this study, just published this month (12/2025), which uses genetic data to propose how disorders might be grouped: https://www.nature.com/articles/s41586-025-09820-3
The findings suggest schizophrenia and bipolar disorders could be grouped together. Overall, what seems to be clear is that it is still not clear, but for me videos like this are helpful for understanding how clinicians approach it.
We know that schizophrenia as we call it is actually a heterogeneous group of diagnoses that we have no ability to segregate at this point.
A guy at the NIH called Christopher Bartley was given a lab to identify auto antibodies that cause schizophrenia. They believe that it may be as many as 20% of cases of schizophrenia that applies to. There are several people that have accidentally been cured with immunosuppressants.
What if someone was originally diagnosed Schizoaffective. They had a change in providers and years gap between care. They then get diagnosed Major Depressive Disorder with a psychotic break not likely to reoccur?
This all based on their self-disclosure and hiding symptoms/issues.
I’d say it’s possible. It’s a spectrum and clinically about 10% of people have psychosis at some point in their lives but only about 1.5% qualify for a schizo- diagnosis. I’m NAD so it’s a difficult concept for me.
I can’t say if that’s appropriate in that individual.
Very helpful!!
what even causes these disorders?
Genetics + environment and/or trauma - either psychological or TBI.
The more I have looked, the more it seems like there is a lot of subjectivity and overlap in diagnoses. I came across this study, just published this month (12/2025), which uses genetic data to propose how disorders might be grouped:
https://www.nature.com/articles/s41586-025-09820-3
The findings suggest schizophrenia and bipolar disorders could be grouped together. Overall, what seems to be clear is that it is still not clear, but for me videos like this are helpful for understanding how clinicians approach it.
We know that schizophrenia as we call it is actually a heterogeneous group of diagnoses that we have no ability to segregate at this point.
A guy at the NIH called Christopher Bartley was given a lab to identify auto antibodies that cause schizophrenia. They believe that it may be as many as 20% of cases of schizophrenia that applies to. There are several people that have accidentally been cured with immunosuppressants.