From Google search AI overview:
Centanafadine is a non-stimulant medication being developed as a treatment for attention-deficit/hyperactivity disorder (ADHD) in children, adolescents, and adults. It functions as a novel norepinephrine, dopamine, and serotonin reuptake inhibitor (NDSRI). In November 2025, its developer, Otsuka Pharmaceutical, submitted a New Drug Application to the U.S. Food and Drug Administration (FDA), supported by positive Phase 3 clinical trial results.
FDA submission news article from developer: https://www.otsuka-us.com/news/otsuka-pharmaceutical-submits-new-drug-application-us-fda-centanafadine-treatment-adhd
Pay attention to this drug everyone. Its a triple reuptake (as said by OP) inhibitor so norepinephrine, dopamine, and serotonin. It might be useful for depression, anxiety and adhd. A lot of comorbid disorders to CDS. On top of that it has the best safety profile of any adhd drug.
Yes, I'm excited about it too. Scared of the price, but hopefully they have a nice savings card to get people on it.
Agreed. I Really hope that this pans out to treat all three conditions. This sub is about CDS but I us to care about general mental health and function as well. The lines we draw between these disorders dont exist in nature. Even though they do help us find treatments