Hey OP! It looks like your submission was a link to some type of scientific article. To ensure your post is high-quality (and not automatically removed for low effort) make sure to post a comment with the abstract of the original peer-reviewed research including some topics and/or questions for discussion. Thanks!
I thought it was already agreed knowledge that stimulants primarily effect the salience network. That isn't part of the attentional networks but it does act to activate them while also suppressing the activity of the default mode network. Failures due to reduced activity in salience leads to under activated attention and continuing competing input from the DMN. If you ponder what that might feel like, you can see how it matches with many of the problems reported by those with ADHD
This is incorrect. The validation sample is n=5, and that's using precision imaging (many repeated measurements in the same brain); that sample alone with a precision-imaging approach gives you enough power to say something interesting. But that was the cherry on top of an initial analysis that had n>5,000! There are surely critiques you can make of the study, but sample size and statistical rigor is not one of them. Out-of-sample validation on top of their initial sample of n>5,000 is more powered and more rigorous than >99% of fMRI studies.
This is interesting because I’ve been prescribed this medicine and I always knew this is how it worked. I didn’t know anyone really thought it affected “attention circuits”.
You kind of DO need to have a certain level of baseline neurological arousal in order to make use of attentional networks. So it’s not surprising that stimulants help people who have ADHD.
The disorder is generally NOT primarily due to deficits in attentional deficits per se, but rather the inability to reliably control/maintain attention.
Hey OP! It looks like your submission was a link to some type of scientific article. To ensure your post is high-quality (and not automatically removed for low effort) make sure to post a comment with the abstract of the original peer-reviewed research including some topics and/or questions for discussion. Thanks!
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I thought it was already agreed knowledge that stimulants primarily effect the salience network. That isn't part of the attentional networks but it does act to activate them while also suppressing the activity of the default mode network. Failures due to reduced activity in salience leads to under activated attention and continuing competing input from the DMN. If you ponder what that might feel like, you can see how it matches with many of the problems reported by those with ADHD
This is an interesting article, but it's worth noting that the sample size is tiny. N=5 for the fMRI analyses.
This is incorrect. The validation sample is n=5, and that's using precision imaging (many repeated measurements in the same brain); that sample alone with a precision-imaging approach gives you enough power to say something interesting. But that was the cherry on top of an initial analysis that had n>5,000! There are surely critiques you can make of the study, but sample size and statistical rigor is not one of them. Out-of-sample validation on top of their initial sample of n>5,000 is more powered and more rigorous than >99% of fMRI studies.
This is interesting because I’ve been prescribed this medicine and I always knew this is how it worked. I didn’t know anyone really thought it affected “attention circuits”.
You kind of DO need to have a certain level of baseline neurological arousal in order to make use of attentional networks. So it’s not surprising that stimulants help people who have ADHD.
The disorder is generally NOT primarily due to deficits in attentional deficits per se, but rather the inability to reliably control/maintain attention.