Hello!
I've had 5 IVF cycles without success. Two spontaneous ectopic pregnancies. My AMH is 3.04. In each cycle I have 8 embryos, 7 embryos, and 6 embryos, but I want to do PGT, but we can't get them to work; they're no longer viable. I don't know what to do anymore. All the analyses are normal.
I mean technically you can do IVF as many times as you can afford, but if you’re not making blasts and you’re not willing to consider day 3 transfers then you probably need to come to terms with it having a very slim success rate.
What do you mean they’re no longer viable? Do you mean they make it to day 3 but not day 5?
If you are getting 6-8 embryos per cycle and sending them all to PGT-A and they are aneuploid, I’d probably talk to a genetic counselor about what exactly the issues with them are and maybe look into kareotype testing. Depending on age of course but if you’re young enough that you’d expect at least some of them to be euploid.
After 3 losses and 5 transfers, I was terrified my clinic would drop me. My RE was extremely reassuring that as long as I kept making viable embryos, he would not give up on me. Currently 30w with twins from transfer #6
Congrats
Try another clinic with different laboratory? Day 3 transfer? This sounds very rough, either way talk to your/ a doctor for options
I’ve done 6 with no success and I decided to throw in the towel. But you have a great AMH and are making lots of embryos. I would continue to go through it if I could afford to do so. If I were you I’d try day 3 transfer instead of waiting to reach blasts. Some clinics will tell you inside the body can give them a better chance than growing in the lab.
We had all the necessary tests done: karyotype analysis, sperm DNA fragmentation, sperm morphology, and HLCA. According to the results, all findings were normal.
The problem is that while the embryos develop to the blastocyst stage, they don't reach the necessary quality to be suitable for PGT.
I had three embryo transfers done in Germany on day 5, as well as one transfer of a frozen embryo, also on day 5 – unfortunately without success.
After that, we went to Turkey. There, we were able to obtain one embryo for PGT, but it showed a chromosomal deletion on chromosomes 7-8.
Then we went to Turkey. Afterwards, we went to the Czech Republic, but even there we weren't able to obtain an embryo for PGT. We were also told there that the sperm morphology was only 2%.
We had the sperm analysis done again afterwards, and the results were good again.
I just don't understand what the real problem is and why our embryos make it to the blastocyst stage but then don't have sufficient quality.
So they are just poorly graded and the clinics aren’t willing to test or transfer them? How old are you? Have you considered transferring them untested?
I did it three times without testing, meaning I performed the transfer on day 5. After that, I decided to do a PGT because I wanted to know what the problem was. However, I still can't understand why they only make it to the blastocyst stage and not further.
If your AMH is so good and other analysis are good as well, I'd do more testing on the "environment". Thyroid tests, maybe you have antibodies that prevents the embryo to implant, do a PCR test as well - you never know what you might find out even with no symptoms. I had no symptoms and found I had ureaplasma, just recently cured it but couldn't get pregnant. There can be so many reasons why, you just don't know them yet. And you need a very good doctor to help you detect whatever the reason is.
A PCR on what?
What do you mean on what? It's a vaginal swap to detect any infections in the reproductive system.
That was my question, you answered it. :)
Like even a Covid swab is a “PCR test”
Oh ok, I'm glad it's all clear now :)