Walker chose Senator Jeff Sessions, an arch-conservative from Alabama, as his running mate in order to unite the GOP and provide experience to the ticket. In the general election, Walker ran on tax cuts, repealing and replacing Obamacare, and a strong defense. Walker, unlike Trump, supported free trade, but called for fairer trade deals and a renegotiation of NAFTA and TPP.

Hillary Clinton emphasized her experience and promised to continue Barack Obama's moderate policies. Clinton attacked Scott Walker for cutting the salaries and benefits of state employees, refusing a $810 million award from the federal Department of Transportation to build a high speed railroad line from Madison to Milwaukee, and opposing abortion in cases of rape.

Despite Trump's strong showing in the primaries, the majority of Republicans coalesced around Walker, who obtained the endorsement of Trump. Hillary Clinton, on the other hand, faced the unwillingness of many Sanders voters to support her in the general election, although a large amount saw Clinton as way more palatable than the run of the mill conservative Walker.

Even with these issues, Clinton led in the polls throughout the campaign, as Walker was seen as an unexciting and uncharismatic candidate. He shocked pundits by winning the election with 284 electoral votes versus 253 for Clinton, who won the popular vote by 500,000 votes.

The tipping point state was Ohio, which Walker won by a margin of 16,000 votes; Clinton kept most of the blue wall, including Michigan and Pennsylvania. Walker and Sessions were inaugurated on January 20, 2017, and began lowering taxes and restricting abortion (within the confines of Roe) and immigration.